Connexin 43/GJA1 anticorps (pSer368)
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- Antigène Voir toutes Connexin 43/GJA1 (GJA1) Anticorps
- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
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Épitope
- pSer368
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Reactivité
- Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Cobaye, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Connexin 43/GJA1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- This antibody specifically recognises 43 kDa Connexin43, when phosphorylated at Ser368.
- Purification
- Affinity chromatography
- Immunogène
- Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368
- Isotype
- IgG
- Top Product
- Discover our top product GJA1 Anticorps primaire
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- Indications d'application
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Western Blot: 1: 1000, detects a band of approximately 43 kDa in rat hippocampus celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES, pH 7.5 containing 0.09 % Sodium Azide, 0.01 % Bovine Serum Albumin, 50 % Glycerol
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
- Autre désignation
- GJA1 / Cx43 (GJA1 Produits)
- Synonymes
- anticorps AVSD3, anticorps CX43, anticorps DFNB38, anticorps GJAL, anticorps HLHS1, anticorps HSS, anticorps ODDD, anticorps Cx43, anticorps AU042049, anticorps AW546267, anticorps Cnx43, anticorps Cx43alpha1, anticorps Gja-1, anticorps Npm1, anticorps connexin43, anticorps cx43a1, anticorps gja1, anticorps zfCx43.3, anticorps connexin 43, anticorps gja1-A, anticorps cx43, anticorps gjal, anticorps oddd, anticorps dfnb38, anticorps gap junction protein alpha 1, anticorps gap junction protein, alpha 1, anticorps connexin 43, anticorps gap junction protein alpha 1 L homeolog, anticorps CONNEXIN 43 protein, anticorps GJA1, anticorps Gja1, anticorps cx43, anticorps gja1.L, anticorps gja1, anticorps CONNEXIN 43
- Sujet
- Connexin43 (CX43) allows for the exchange of solutions between neighbouring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. Studies suggest that a decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C (PKC). A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumours and peritumoural reactive astrocytes (3).Synonyms: Connexin-43, GJAL, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein
- ID gène
- 2697
- NCBI Accession
- NP_000156
- UniProt
- P17302
- Pathways
- Signalisation MAPK, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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