BACE1 anticorps

N° du produit ABIN325261

Cet anticorps Souris Monoclonal détecte spécifiquement BACE1 dans WB, ELISA, IP et Neut. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour BACE1 anticorps (ABIN325261)

Antigène: BACE1 (Beta-secretase 1 (BACE1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BACE1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Neutralization (Neut)

Détail du produit anti-BACE1 anticorps

Specificité: Recognizes human BACE-1 ectodomain. Species cross-reactivity: Mouse.

Purification: Protein G purified

Immunogène: NS0-derived rhBACE-1 ectodomain.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, IP, Neut, WB

Usage: Suitable for use in ELISA, Immunoprecipitation/ Western Blot and Neutralization. The enzyme was then assayed with a peptide substrate. 50 % of the proteolytic activity was inhibited by the antibody at 10 μg/mL (IC50) under conditions in which the enzyme was present at 10 μg/mL and the substrate concentration was 10uM. Considering the molecular masses of the enzyme (75kD) and the antibody (150kD), IC50 was achieved at ~0.5:1 Molar ratio of the antibody to the enzyme. Did not inhibit rhCathepsin D activity under the same conditions.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Sterile PBS

Concentration: Lot specific

Buffer: Lyophilized, PBS,  pH 7.4, 5 % trehalose

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur BACE1

Antigène: BACE1 (Beta-secretase 1 (BACE1))

Autre désignation: BACE1 / BACE

Sujet: Name/Gene ID: BACE1
Subfamily: Aspartic A1
Family: Protease

Synonyms: BACE1, APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, Aspartylprotease 2, Beta-secretase, Beta-site APP-cleaving enzyme, BACE, HSPC104, KIAA1149, B-Secretase, Beta-secretase 1, Memapsin-2

ID gène: 23621

UniProt: P56817