CD176 anticorps

N° du produit ABIN336906

Détail du produit anti-CD176 anticorps

Antigène: CD176 (Thomsen Friedenreich Antigen (CD176))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD176 est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Alpha GalNacOSer/Thr. Molecular Weight: several HM weight glycoproteins.

Immunogène: Asialo ovine submaxillary mucin (AOSM)

Clone: Tn218

Isotype: IgM

Information d'application

Indications d'application: IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears) Dilute conc. antibodies 1:50-1:100 using streptavidin-Biotin system or polymer system for 30 minutes at RT. Prediluted antibody is used directly without dilution. The optimum dilution should be determined by the individual lab. Positive Control: Human gastrointestinal tumor. Cellular Localization: Cytoplasmic and epithelial membrane.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The antibodies are supplied as concentrated cell culture medium in PBS with 0.05% azide, pH 7.4. The Prediluted antibody is supplied in our Universal antibody dilution buffer (AR-6526) green in color.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur CD176

Antigène: CD176 (Thomsen Friedenreich Antigen (CD176))

Autre désignation: Thomsen Friedenreich Antigen (CD176 Produits)

Sujet: Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator. This antibody stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach, breast.