ORAI3 anticorps (N-Term)
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- Antigène Voir toutes ORAI3 Anticorps
- ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
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Épitope
- N-Term
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ORAI3 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Marque
- IHC-plus™
- Specificité
- Recognizes human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. AHP1496 is not expected to cross react with either ORAI1 or ORAI2.
- Purification
- Affinity purified
- Immunogène
- A 15 amino acid peptide from near the amino terminus of human ORAI3.
- Top Product
- Discover our top product ORAI3 Anticorps primaire
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- Indications d'application
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Approved: IHC, IHC-P (5 μg/mL), WB
Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 5 μg/mL. Western Blot: LS-B2385 detects a band of approximately 35kD in A20 cell lysates. - Commentaires
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing. Store undiluted.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 4°C or -20°C, Avoid freeze-thaw cycles. Store undiluted.
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- Antigène
- ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
- Autre désignation
- ORAI3 (ORAI3 Produits)
- Synonymes
- anticorps ORAI3, anticorps TMEM142C, anticorps 9930124N15, anticorps BC061259, anticorps Tmem142c, anticorps RGD1306538, anticorps ORAI calcium release-activated calcium modulator 3, anticorps ORAI3, anticorps Orai3
- Sujet
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Name/Gene ID: ORAI3
Synonyms: ORAI3, Protein orai-3, TMEM142C, Transmembrane protein 142C - ID gène
- 93129
- UniProt
- Q9BRQ5
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