ORAI3 anticorps (C-Term)

N° du produit ABIN500427

Cet anticorps anti-ORAI3 Polyclonal Lapin (ABIN500427) détecte spécifiquement ORAI3 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour ORAI3 anticorps (C-Term) (ABIN500427)

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORAI3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-ORAI3 anticorps

Épitope: C-Term

Specificité: This antibody detects ORAI3 at C-term. It i predicted to have no cross-reactivity to ORAI1 or ORAI2.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: ORAI3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ORAI3.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2 - 4 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ORAI3

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Autre désignation: ORAI3

Sujet: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C

ID gène: 93129

UniProt: Q9BRQ5