KLKB1 anticorps

N° du produit ABIN342152

L’anticorps anti-KLKB1 Monoclonal Souris est utilisé pour la détection de KLKB1 dans des échantillons de Humain. Il a été validé pour ELISA et WB.

Aperçu rapide pour KLKB1 anticorps (ABIN342152)

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KLKB1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Clone: 13G11

Détail du produit anti-KLKB1 anticorps

Specificité: Specifically recognizes in human plasma two variants (88 kD and 85 kD) of prekallikrein and its activation products kallikrein (88 kD and 85 kD), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kD prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue kallikrein.

Purification: Protein G purified

Immunogène: Human plasma prekallikrein.

Type of Immunogen: Purified protein

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, WB

Usage: May be used in ELISA and Western blots to identify/quantitate prekallikrein and its activation products in plasmas of humans, chimpanzees, rhesus monkeys, and baboons. NOTE: Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples obtained from humans or other primates.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur KLKB1

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Autre désignation: KLKB1 / Plasma Kallikrein

Sujet: Name/Gene ID: KLKB1
Subfamily: Serine S1
Family: Protease

Synonyms: KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3

ID gène: 3818

UniProt: P03952

Pathways: Système du Complément, Brown Fat Cell Differentiation