KLKB1 anticorps

N° du produit ABIN342152

Détail du produit anti-KLKB1 anticorps

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KLKB1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: Specifically recognizes in human plasma two variants (88 kD and 85 kD) of prekallikrein and its activation products kallikrein (88 kD and 85 kD), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kD prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue kallikrein.

Purification: Protein G purified

Immunogène: Human plasma prekallikrein.

Type of Immunogen: Purified protein

Clone: 13G11

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, WB

Usage: May be used in ELISA and Western blots to identify/quantitate prekallikrein and its activation products in plasmas of humans, chimpanzees, rhesus monkeys, and baboons. NOTE: Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples obtained from humans or other primates.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur KLKB1

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Autre désignation: KLKB1 / Plasma Kallikrein (KLKB1 Produits)

Synonymes: anticorps KLK3, anticorps PPK, anticorps APS, anticorps Kal-3, anticorps Kal3, anticorps Klk3, anticorps PSA, anticorps KALP15, anticorps Kalp1, anticorps KLKB1, anticorps DKFZp459J2015, anticorps klkb1, anticorps kallikrein B1, anticorps kallikrein B, plasma 1, anticorps plasma kallikrein, anticorps Plasma kallikrein, anticorps kallikrein B, plasma (Fletcher factor) 1, anticorps coagulation factor XI, anticorps kallikrein B1 L homeolog, anticorps KLKB1, anticorps Klkb1, anticorps CpipJ_CPIJ004042, anticorps CpipJ_CPIJ014955, anticorps CpipJ_CPIJ020108, anticorps VAA_02266, anticorps LOC100549617, anticorps klkb1, anticorps klkb1.L

Sujet: Name/Gene ID: KLKB1
Subfamily: Serine S1
Family: Protease

Synonyms: KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3

ID gène: 3818

UniProt: P03952

Pathways: Système du Complément, Brown Fat Cell Differentiation