LBP anticorps

N° du produit ABIN343173

Cet anticorps anti-LBP est un anticorps Souris Monoclonal détectant LBP dans ELISA. Adapté pour Souris. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour LBP anticorps (ABIN343173)

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LBP est non-conjugé

Application: ELISA

Clone: BiG33

Détail du produit anti-LBP anticorps

Specificité: Mouse LBP. The antibody blocks LPS binding to membrane bound CD14.

Réactivité croisée: Humain, Rat (Rattus)

Purification: Protein G affinity column

Immunogène: native mouse LBP

Isotype: IgG1

Information d'application

Indications d'application: ELISA ,LBP inhibition studies, Western Blot. inhibits binding of LPS to membrane bound CD14, (Inhibits LPS-binding (0.5 ug/ml) to CD14+CHO cells (2 x 106/ml) up to 1:1000, total inhibition 1:5 Binding titre at mouse LBP- ELISA: 1:50.000 Cross reacting with rat LBP

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with bidistilled water

Concentration: 1 mg/mL

Buffer: PBS, pH 7.17

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Références pour anticorps anti-LBP (ABIN343173)

Dziarski, Tapping, Tobias: "Binding of bacterial peptidoglycan to CD14." dans: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).

Weidemann, Schletter, Dziarski, Kusumoto, Stelter, Rietschel, Flad, Ulmer: "Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes." dans: Infection and immunity, Vol. 65, Issue 3, pp. 858-64, (1997) (PubMed).

Détails sur LBP

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Autre désignation: Lipopolysaccharide (LPS)-Binding Protein (LBP)

Sujet: Background: Natural LBP is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.

Poids moléculaire: ~58kDa

ID gène: 16803

UniProt: Q61805

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process