LBP anticorps

N° du produit ABIN343175

L’anticorps Souris Monoclonal anti-LBP a été validé pour IHC (p). Il convient pour détecter LBP dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour LBP anticorps (ABIN343175)

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LBP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BiG42

Détail du produit anti-LBP anticorps

Specificité: Human LBP (Lipopolysaccaride binding protein). The antibody don't block LPS binding to membrane bound CD14.

Réactivité croisée: Boeuf (Vache), Chien, Cheval, Lapin

Purification: Protein A affinity column

Immunogène: native human LBP

Isotype: IgG1

Information d'application

Indications d'application: ELISA, Immune histology at paraffin sections, LBP inhibition studies, Western Blot. No inhibition of LPS binding to membrane bound CD14 Binding titre at human LBP- ELISA: 1:10.000

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with bidistilled water

Concentration: 1 mg/mL

Buffer: PBS, pH 7.12

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Références pour anticorps anti-LBP (ABIN343175)

Eckert, Kim, Kim, Gürtler, Oh, Sur, Lundvall, Hamann, van der Ploeg, Pickkers, Giamarellos-Bourboulis, Kubarenko, Weber, Kabesch, Kumpf, An, Lee, Schumann: "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." dans: Immunity, Vol. 39, Issue 4, pp. 647-60, (2013) (PubMed).

Rahman, Lecchi, Avallone, Roccabianca, Sartorelli, Ceciliani: "Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues." dans: Veterinary immunology and immunopathology, (2010) (PubMed).

Ren, Jin, Leung: "Local expression of lipopolysaccharide-binding protein in human gingival tissues." dans: Journal of periodontal research, Vol. 39, Issue 4, pp. 242-8, (2004) (PubMed).

Détails sur LBP

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Autre désignation: Lipopolysaccharide (LPS)-Binding Protein (LBP)

Sujet: Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.

Poids moléculaire: ~58kDa

ID gène: 3929

NCBI Accession: NP_004130

UniProt: P18428

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process