LBP anticorps

N° du produit ABIN343177

Cet anticorps Souris Monoclonal détecte spécifiquement LBP dans ELISA et Func. Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour LBP anticorps (ABIN343177)

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LBP est non-conjugé

Application: ELISA, Functional Studies (Func)

Clone: BiG 412

Détail du produit anti-LBP anticorps

Purification: Protein G purified

Immunogène: LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP

Isotype: IgG1

Information d'application

Indications d'application: inhibition of LPS binding to membrane bound CD14, inhibition titre 1:1000. Binding titre at human LBP- ELISA: 1:50.000, cross reacting with bovine LBP.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: 2.0 mg/ml (determined by mouse IgG-ELISA) before lyophilization

Buffer: with NaN3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-LBP (ABIN343177)

Muansson, Kjaell, Pellett, Nagy, Welch, Baeckhed, Frisan, Richter-Dahlfors: "Role of the lipopolysaccharide-CD14 complex for the activity of hemolysin from uropathogenic Escherichia coli." dans: Infection and immunity, Vol. 75, Issue 2, pp. 997-1004, (2007) (PubMed).

Kato, Ogasawara, Homma, Saito, Matsumoto: "Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6185-94, (2004) (PubMed).

Berner, Fürll, Stelter, Dröse, Müller, Schütt: "Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis." dans: Clinical and diagnostic laboratory immunology, Vol. 9, Issue 2, pp. 440-5, (2002) (PubMed).

Vidal, Labéta, Schiffrin, Donnet-Hughes: "Soluble CD14 in human breast milk and its role in innate immune responses." dans: Acta odontologica Scandinavica, Vol. 59, Issue 5, pp. 330-4, (2001) (PubMed).

Détails sur LBP

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Autre désignation: Lipopolysaccharide (LPS)-Binding Protein (LBP)

Sujet: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process