Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CD8 alpha anticorps (PE)

CD8A Reactivité: Souris FACS Hôte: Rat Monoclonal 53-6-7 PE
N° du produit ABIN349711
  • Antigène Voir toutes CD8 alpha (CD8A) Anticorps
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Reactivité
    • 213
    • 130
    • 46
    • 37
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Souris
    Hôte
    • 170
    • 130
    • 111
    • 1
    Rat
    Clonalité
    • 308
    • 100
    • 1
    Monoclonal
    Conjugué
    • 135
    • 46
    • 30
    • 29
    • 29
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD8 alpha est conjugé à/à la PE
    Application
    • 309
    • 111
    • 100
    • 69
    • 61
    • 50
    • 44
    • 25
    • 16
    • 15
    • 14
    • 11
    • 10
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The rat monoclonal antibody 53-6.7 recognizes an extracellular epitope of murine CD8a (32-34 kDa, alpha chain of the CD8 antigen).
    Réactivité croisée (Details)
    Mouse
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Murine spleen cells
    Clone
    53-6-7
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CD8A Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 2 μg/mL.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Mochimaru, Usui, Yaguchi, Nagahama, Hasegawa, Usui, Shimmura, Tsubota, Amano, Kawakami, Ishida: "Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2." dans: Investigative ophthalmology & visual science, Vol. 49, Issue 5, pp. 2172-7, (2008) (PubMed).

    Bouwer, Alberti-Segui, Montfort, Berkowitz, Higgins: "Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 13, pp. 5102-7, (2006) (PubMed).

    Kamimura, Sawa, Sato, Agung, Hirano, Murakami: "IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 306-14, (2006) (PubMed).

    Hata, Sakaguchi, Yoshitomi, Iwakura, Sekikawa, Azuma, Kanai, Moriizumi, Nomura, Nakamura, Sakaguchi: "Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice." dans: The Journal of clinical investigation, Vol. 114, Issue 4, pp. 582-8, (2004) (PubMed).

    Grabbe, Varga, Beissert, Steinert, Pendl, Seeliger, Bloch, Peters, Schwarz, Sunderkötter, Scharffetter-Kochanek: "Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells." dans: The Journal of clinical investigation, Vol. 109, Issue 2, pp. 183-92, (2002) (PubMed).

    Takahashi, Nakata, Tanaka, Adachi, Nakauchi, Yagita, Okumura: "CD4 and CD8 regulate interleukin 2 responses of T cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5557-61, (1992) (PubMed).

    Ledbetter, Herzenberg: "Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens." dans: Immunological reviews, Vol. 47, pp. 63-90, (1980) (PubMed).

    Ledbetter, Rouse, Micklem, Herzenberg: "T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views." dans: The Journal of experimental medicine, Vol. 152, Issue 2, pp. 280-95, (1980) (PubMed).

  • Antigène
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Autre désignation
    CD8a (CD8A Produits)
    Synonymes
    anticorps cd8, anticorps LOC100136450, anticorps BB154331, anticorps Ly-2, anticorps Ly-35, anticorps Ly-B, anticorps Lyt-2, anticorps zgc:136643, anticorps CD8, anticorps Leu2, anticorps MAL, anticorps p32, anticorps RHACD8-4, anticorps CD8a molecule, anticorps uncharacterized LOC100125537, anticorps CD8 alpha, anticorps CD8 antigen, alpha chain, anticorps T-cell surface glycoprotein CD8 alpha chain, anticorps Cd8a, anticorps LOC100125537, anticorps LOC100136450, anticorps CD8A, anticorps cd8a, anticorps LOC100126556
    Sujet
    CD8a molecule,The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-2, Ly-B, Ly-35, Lyt-2, BB154331
    ID gène
    12525
    UniProt
    P01731
    Pathways
    TCR Signaling
Vous êtes ici:
Support technique