LC3C anticorps

N° du produit ABIN350463

Cet anticorps anti-LC3C est un anticorps Mouton Polyclonal détectant LC3C dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour LC3C anticorps (ABIN350463)

Antigène: LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))

Reactivité: Humain

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp LC3C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-LC3C anticorps

Fonction: Sheep antibody to MAP1LC3C

Specificité: Specific for MAP1LC3C.

Réactivité croisée: Humain

Réactivité croisée (Details): Other species not yet tested.

Purification: IgG

Immunogène: A synthetic peptide from human microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C MAP1A/MAP1B LC3 C) conjugated to an immunogenic carrier protein has been used as the immunogen.

Isotype: IgG

Information d'application

Indications d'application: IHC WB. Use at a concentration of 10-50,micro,g,ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur LC3C

Antigène: LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))

Autre désignation: MAP1LC3C

Sujet: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation metamorphosis non-apoptotic cell death and aging. Reduced levels of autophagy have been described in some malignant tumors and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes). SUBUNIT: 3 different light chains LC1 LC2 and LC3 can associate with MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane, Lipid-anchor. Cytoplasmic vesicle autophagosome membrane, Lipid-anchor. Note: LC3-II binds to the autophagic membranes. TISSUE SPECIFICITY: Most abundant in placenta lung and ovary. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form LC3-I. This is activated by APG7L/ATG7 transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form LC3-II.

UniProt: Q9BXW4

Pathways: Autophagy