S100A1 anticorps

N° du produit ABIN356473

Cet anticorps Lapin Polyclonal détecte spécifiquement S100A1 dans IF, IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Boeuf (Vache) et Singe.

Aperçu rapide pour S100A1 anticorps (ABIN356473)

Antigène: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S100A1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-S100A1 anticorps

Specificité: This antibody stains schwannoma, ependymomas, astrogliomas, almost all benign and malignant melanoma and their metasis. Cellular localization: Cytoplasmic.

Réactivité croisée (Details): Species reactivity (expected):Monkey, Rat and Mouse.
Species reactivity (tested):Human, Bovine.

Purification: Protein A Chromatography

Immunogène: Purified S100 protein from Bovine.

Isotype: IgG

Information d'application

Indications d'application: Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears): 1/50-1/100 usingstreptavidinapprox. biotin system or polymer system. Immunofluorescence. Positive control: Melanoma or schwannoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 10 mM PO4, 150 mM NaCl, pH 7.4 containing 1 % BSA and 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: This antibody should not be diluted in Buffer which contains Detergent.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur S100A1

Antigène: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Autre désignation: S100A1

Sujet: S100 protein is a type of low molecular weight protein found in vertebrates characterized by two calcium binding sites of the helix-loop-helix ("EF-hand type") conformation. There are at least 21 different types of S100 proteins. The name is derived from the fact that the protein is 100 % Soluble in ammonium sulfate at neutral pH . Most S100 proteins are homodimeric, consisting of two identical polypeptides held together by non-covalent bonds. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. Although S100 proteins are structurally similar to calmodulin, they differ in that they are cell-specific, expressed in particular cells at different levels depending on environmental factors. To contrast, calmodulin is a ubiquitous and universal intracellular Ca++ receptor widely expressed in many cells.S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glia cells), chondrocyte, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes. It may be present in some breast epithelial cells.Synonyms: Astrocyte Marker, S-100 protein, S-100 protein alpha chain, S-100 protein alpha subunit, S-100 protein beta chain, S-100 protein beta subunit, S100 Alpha, S100 Beta, S100 Calcium binding protein, S100A, S100B

ID gène: 6271

NCBI Accession: NP_006262

UniProt: P23297

Pathways: Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins