PIAS4 anticorps (N-Term)

N° du produit ABIN356770

Cet anticorps Lapin Polyclonal détecte spécifiquement PIAS4 dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour PIAS4 anticorps (N-Term) (ABIN356770)

Antigène: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIAS4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-PIAS4 anticorps

Épitope: N-Term

Specificité: This antibody is specific to PIASy (N-term).

Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIASy1.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Reported to work in Immunoprecipitation (See Ref.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PIAS4

Antigène: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Autre désignation: PIAS4

Sujet: PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.Synonyms: E3 SUMO-protein ligase PIAS4, PIAS-gamma, PIASG, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma

ID gène: 51588, 9606

UniProt: Q8N2W9

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus