ACO2 anticorps (Center)

N° du produit ABIN357262

Détail du produit anti-ACO2 anticorps

Antigène: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Épitope: Center

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACO2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects ACO2 at center.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human Aconitase.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA 1: 1,000. Western blot 1: 100 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-ACO2 (ABIN357262)

Carpenter, Paw, Dewhirst, Lo: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." dans: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).

Fernandes, Uytterhoeven, Kuenen, Wang, Slabbaert, Swerts, Kasprowicz, Aerts, Verstreken: "Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration." dans: The Journal of cell biology, Vol. 207, Issue 4, pp. 453-62, (2014) (PubMed).

Maity, Bindu, Dey, Goyal, Alam, Pal, Mitra, Bandyopadhyay et al.: "Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel ..." dans: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3058-68, (2009) (PubMed).

OConnell, Gannon, Doran, Ohlendieck: "Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle." dans: International journal of molecular medicine, Vol. 20, Issue 2, pp. 145-53, (2007) (PubMed).

Détails sur ACO2

Antigène: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Autre désignation: ACO2 (ACO2 Produits)

Synonymes: anticorps DDBDRAFT_0206187, anticorps DDBDRAFT_0230168, anticorps DDB_0206187, anticorps DDB_0230168, anticorps aconitase 2, anticorps F10M23.310, anticorps F10M23_310, anticorps ACONM, anticorps ICRD, anticorps Aco-2, anticorps Aco3, anticorps D10Wsu183e, anticorps cb1017, anticorps wu:fa10e03, anticorps wu:fb69g04, anticorps wu:fc20c11, anticorps aconitase 2, anticorps aconitase 2 S homeolog, anticorps aconitate hydratase, mitochondrial, anticorps aconitase, mitochondrial, anticorps mitochondrial aconitate hydratase, anticorps aconitase 2, mitochondrial, anticorps Probable aconitate hydratase, mitochondrial, anticorps ACO2, anticorps aco2.S, anticorps Bm1_07420, anticorps aco2, anticorps ach1, anticorps Aco2, anticorps aco-2

Sujet: ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.Synonyms: Aconitase 2, Aconitate hydratase mitochondrial

Poids moléculaire: 85425 Da.

ID gène: 50, 9606

UniProt: Q99798