USP8 anticorps (C-Term)

N° du produit ABIN357535

Détail du produit anti-USP8 anticorps

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody is specific to USP8/UBPY (C-term). Predicted to cross react with Mouse (100 % Antigen Homology).

Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human USP8.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur USP8

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Autre désignation: USP8 / UBPY (USP8 Produits)

Synonymes: anticorps HumORF8, anticorps UBPY, anticorps AI574262, anticorps AW557536, anticorps Ubpy, anticorps mKIAA0055, anticorps ubiquitin carboxyl-terminal hydrolase 8, anticorps ubiquitin specific peptidase 8, anticorps LOC9310109, anticorps MGYG_00369, anticorps USP8, anticorps Usp8

Sujet: USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.Synonyms: Deubiquitinating enzyme 8, KIAA0055, Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin thioesterase 8, Ubiquitin-specific-processing protease 8

Poids moléculaire: 127523 Da

ID gène: 9101, 5874

UniProt: P40818