HGS anticorps (N-Term)
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- Antigène Voir toutes HGS Anticorps
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HGS est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody is specific to HGS (N-term).
- Purification
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Immunogène
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human HGS.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product HGS Anticorps primaire
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- Indications d'application
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ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Antigène
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
- Autre désignation
- HGS / HRS (HGS Produits)
- Synonymes
- anticorps HRS, anticorps Hrs, anticorps fi34f05, anticorps zgc:63492, anticorps wu:fi34f05, anticorps Hgr, anticorps ZFYVE8, anticorps CG2903, anticorps Dmel\\CG2903, anticorps HRS-2, anticorps Vps27, anticorps hrs, anticorps l(2)23AB5, anticorps l(2)23Ad, anticorps l(2)23Ad(Hrs), anticorps vps27, anticorps hgs, anticorps hepatocyte growth factor-regulated tyrosine kinase substrate, anticorps HGF-regulated tyrosine kinase substrate, anticorps Hepatocyte growth factor regulated tyrosine kinase substrate, anticorps hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog, anticorps HGS, anticorps Hgs, anticorps hgs, anticorps Hrs, anticorps hgs.L
- Sujet
- HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate, Protein pp110
- Poids moléculaire
- 86192 Da
- ID gène
- 9146, 9606
- UniProt
- O14964
- Pathways
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
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