TSC1 anticorps (pSer505)

N° du produit ABIN358402

Détail du produit anti-TSC1 anticorps

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Épitope: pSer505

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSC1 est non-conjugé

Application: Enzyme Immunoassay (EIA)

Specificité: This antibody detects TSC1 pSer505.

Purification: Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: TSC1 / Hamartin (TSC1 Produits)

Synonymes: anticorps LAM, anticorps TSC, anticorps hamartin, anticorps mKIAA0243, anticorps tsc1, anticorps wu:fc38b04, anticorps fa99f04, anticorps wu:fa99f04, anticorps zgc:63657, anticorps TSC complex subunit 1, anticorps tuberous sclerosis 1, anticorps TSC complex subunit 1b, anticorps TSC complex subunit 1a, anticorps TSC1, anticorps Tsc1, anticorps tsc1b, anticorps tsc1, anticorps tsc1a

Sujet: TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein

Poids moléculaire: 129767 Da

ID gène: 7248, 9606

UniProt: Q92574

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation