TLK2 anticorps (Middle Region)

N° du produit ABIN360577

Détail du produit anti-TLK2 anticorps

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLK2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human TLK2.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur TLK2

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Autre désignation: TLK2 (TLK2 Produits)

Synonymes: anticorps tlk2, anticorps MGC149057, anticorps HsHPK, anticorps PKU-ALPHA, anticorps wu:fi16h09, anticorps wu:fi30g12, anticorps zgc:136697, anticorps 4933403M19Rik, anticorps PKUalpha, anticorps Tlk, anticorps tousled like kinase 2, anticorps tousled-like kinase 2, anticorps tousled-like kinase 2 (Arabidopsis), anticorps tlk2, anticorps TLK2, anticorps Tlk2

Sujet: TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.Synonyms: PKU-alpha, Serine/threonine-protein kinase tousled-like 2, Tousled-like kinase 2

ID gène: 5874

UniProt: Q86UE8