VEGFC anticorps

N° du produit ABIN360866

L’anticorps Souris Monoclonal anti-VEGFC a été validé pour WB et IHC (fro). Il convient pour détecter VEGFC dans des échantillons de Humain et Rat.

Aperçu rapide pour VEGFC anticorps (ABIN360866)

Antigène: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp VEGFC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 9-00E-007

Détail du produit anti-VEGFC anticorps

Specificité: This antibody detects VEGF-C in Western Blots. No cross-reactivity is shown with VEGF-A.

Purification: Protein G Affinity Chromatography

Immunogène: Recombinant Human VEGF-C protein

Isotype: IgG2a

Information d'application

Indications d'application: Western Blot. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in Sterile Water to a concentration of 0.1-1.0 mg/mL. Centrifuge vial prior to opening.

Buffer: Phosphate-Buffered Saline (PBS)

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to and following reconstitution store the antibody at -20 °C.

Détails sur VEGFC

Antigène: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Autre désignation: VEGF-C / Flt4-L

Sujet: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.Synonyms: Flt4 ligand, VEGFC, VRP, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein

ID gène: 7424

NCBI Accession: NP_005420

UniProt: P49767

Pathways: Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2