Decorin anticorps

N° du produit ABIN360879

Cet anticorps anti-Decorin Monoclonal Rat (Clone 9A38) (ABIN360879) détecte spécifiquement Decorin dans WB. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour Decorin anticorps (ABIN360879)

Antigène: Decorin (DCN)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Decorin est non-conjugé

Application: Western Blotting (WB)

Clone: 9A38

Détail du produit anti-Decorin anticorps

Specificité: This antibody detects Mouse Decorin in Western blotting.

Purification: Protein A/G affinity chromatography

Immunogène: Recombinant Decorin

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: 0.2 μm filtered PBS solution

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Decorin

Antigène: Decorin (DCN)

Autre désignation: Decorin

Sujet: Secreted chondroitin/dermatan sulfate proteoglycan belonging to the class I small leucine-rich proteoglycan family (SLRP). All SLRP family members are characterized by the Nterminal and C terminal cysteine rich regions, which flank the central region containing 1012 tandem leucinerich repeats. In mouse Decorin, the glycosaminoglycan chain is Olinked to Ser34 in the Nterminal disulfide bridged loop. Decorin binds to fibronectin, TGFβ, type I and type II collagen. The binding of Decorin to these molecules is mediated via the core protein. Decorin plays a role in maintaining collagen fibrillogenesis. Depending on the cell context, Decorin can either block or augment the bioactivity of TGFβ Decorin induces growth suppression by activation of a signaling pathway that culminates in the blockade of the cell cycle machinery. Decorin can also induce fibroblast cytoskeletal and signalling changes that results in an increased cell migration (1 2).Synonyms: Bone proteoglycan II, DCN, PG-S2, PG40, SLRR1B

ID gène: 13179

NCBI Accession: NP_001177380

UniProt: P28654

Pathways: Glycosaminoglycan Metabolic Process