GAS6 anticorps

N° du produit ABIN360889

Cet anticorps Rat Monoclonal détecte spécifiquement GAS6 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour GAS6 anticorps (ABIN360889)

Antigène: GAS6 (Growth Arrest-Specific 6 (GAS6))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp GAS6 est non-conjugé

Application: Western Blotting (WB)

Clone: 6J2

Détail du produit anti-GAS6 anticorps

Specificité: The monoclonal antibody detects Gas6.

Purification: Protein A/G Affinity Chromatography

Immunogène: Purified Mouse Recombinant Gas6

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: 0.2 μm filtered PBS without preservatives or stabilizers

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GAS6

Antigène: GAS6 (Growth Arrest-Specific 6 (GAS6))

Autre désignation: GAS6 / AXLLG

Sujet: Gas6 (Growth Arrest Specific 6) is one of six structurally unrelated proteins that are secreted by a wide variety of cell types in response to growth arrest. Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively gamma-carboxylated N-terminal Gla domain, four EGF like repeats, and a C-terminal region with homology to steroid hormone binding globulin (SHBG). Human Gas6 is a 75 kDa protein that shares 77 % -79 % aa sequence identity with mouse and rat Gas6. Alternate splicing generates isoforms that lack the Gla domain and/or the spacer between the EGF-like and SHBG regions. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer. Human Gas6 interacts with both mouse and rat orthologs of these receptors. The full length isoform may be cleaved, resulting in release of the free SHBG region which can independently activate Axl. Shed soluble forms of Axl and Mer bind Gas6 and function as decoy receptors.Synonyms: AXL receptor tyrosine kinase ligand, GAS-6, Growth arrest-specific protein 6

ID gène: 2621

NCBI Accession: NP_000811

UniProt: Q14393

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response