FLT1 anticorps (C-Term)

N° du produit ABIN360964

Cet anticorps Lapin Polyclonal détecte spécifiquement FLT1 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour FLT1 anticorps (C-Term) (ABIN360964)

Antigène: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-FLT1 anticorps

Épitope: C-Term

Séquence: CNKKAVFSRI SKFKSTRNDS TTQSNVKH

Specificité: This antibody recognizes the recombinant soluble VEGFR-1/FLT-1 (native) but not the recombinant soluble VEGFR-1/FLT-1 (D1-5) both produced in Insects cells. Because of the different glycosylation of insect cells compared to mammalian cells the MW of sFlt-1 (native) is about 96 kDa instead of about 110 kDa of the naturally occurring sFlt-1. The antibody did not cross react with recombinant Human soluble KDR (D1-7).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein A Chromatography.

Immunogène: Peptide of the C-terminal end of native Human soluble VEGFR-1/Flt-1

Isotype: IgG

Information d'application

Indications d'application: Western Blot: This VEGFR1 antibody can be used at 0.5-2.0 μg/mL with the appropriatesecondary reagents to detect native Human sVEGFR-1/Flt-1. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in sterile water to a concentration of > 0.5 mg/mL

Buffer: PBS, pH 7.2 without preservatives or stabilizers.

Agent conservateur: Without preservative

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur FLT1

Antigène: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Autre désignation: VEGFR-1 / Flt-1

Sujet: Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulinlike sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors, including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.Synonyms: FLT, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGF Receptor 1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor

ID gène: 2321

NCBI Accession: NP_001153392

UniProt: P17948

Pathways: Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals