GRIN2C anticorps (N-Term)

N° du produit ABIN361398

Cet anticorps anti-GRIN2C est un anticorps Lapin Polyclonal détectant GRIN2C dans WB et IP. Adapté pour Rat. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour GRIN2C anticorps (N-Term) (ABIN361398)

Antigène: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIN2C est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-GRIN2C anticorps

Épitope: N-Term

Specificité: Specific for the ~140k NR2C subunit of the NMDA receptor. Also labels the ~180k NR2A and the ~180k NR2B subunits of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Fusion protein from the N-terminal region of the NR2C subunit

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC, IF (frozen sections, unpublished observations): 1:1000 to 1:2000 IP: 3 µl per 200 µg lysate Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized

Stock: -20 °C

Références pour anticorps anti-GRIN2C (ABIN361398)

Wang, Imamura, Ishibashi, Chandana, Yamamoto, Noda: "The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice." dans: Journal of neurochemistry, (2010) (PubMed).

Détails sur GRIN2C

Antigène: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Autre désignation: GRIN2C

Sujet: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Anti-NMDA Receptor, NR2C Subunit Western blot of 10 ug of rat cerebellar lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor.

Poids moléculaire: '140 kDa

ID gène: 24411

UniProt: Q00961

Pathways: Synaptic Membrane