Tyrosine Hydroxylase anticorps

N° du produit ABIN361413

Détail du produit anti-Tyrosine Hydroxylase anticorps

Antigène: Tyrosine Hydroxylase (TH)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tyrosine Hydroxylase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Specificité: Specific for the ~60k tyrosine hydroxylase protein.

Réactivité croisée: Mammifères

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IF (frozen sections, Xu et al., 1998): 1:1000 IHC (frozen sections, Xu et al., 1998): 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-Tyrosine Hydroxylase (ABIN361413)

Sanyal, Dutta, Camara, Chandran, Koller, Watson, Sengupta, Ysselstein, Montenegro, Cannon, Rochet, Mattoo: "Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease." dans: Journal of molecular biology, Vol. 431, Issue 12, pp. 2266-2282, (2020) (PubMed).

Brindley, Bauer, Walker, Quinlan, Carneiro, Sze, Blakely, Currie: "Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter." dans: Pharmacological research, Vol. 140, pp. 56-66, (2019) (PubMed).

de Rus Jacquet, Timmers, Ma, Thieme, McCabe, Vest, Lila, Rochet: "Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms." dans: Journal of ethnopharmacology, Vol. 206, pp. 408-425, (2018) (PubMed).

de Rus Jacquet, Tambe, Ma, McCabe, Vest, Rochet: "Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms." dans: Journal of ethnopharmacology, Vol. 206, pp. 393-407, (2018) (PubMed).

Salvatore, Waymire, Haycock: "Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ." dans: Journal of neurochemistry, Vol. 79, Issue 2, pp. 349-60, (2001) (PubMed).

Détails sur Tyrosine Hydroxylase

Antigène: Tyrosine Hydroxylase (TH)

Autre désignation: Tyrosine Hydroxylase (TH Produits)

Synonymes: anticorps DYT14, anticorps DYT5b, anticorps TYH, anticorps The, anticorps CG10118, anticorps DH65B, anticorps DTH, anticorps Dmel\\CG10118, anticorps Pale, anticorps Ple, anticorps TH, anticorps Th, anticorps VII, anticorps dTH1, anticorps dTH65B, anticorps pale/ple, anticorps th, anticorps dyt14, anticorps dyt5b, anticorps tyh, anticorps tyrosine hydroxylase, anticorps pale, anticorps tyrosine 3-monooxygenase, anticorps tyrosine hydroxylase S homeolog, anticorps TH, anticorps Th, anticorps ple, anticorps th, anticorps th.S, anticorps LOC100008895

Sujet: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000, Salvatore et al., 2001, Dunkley et al., 2004). Anti-Tyrosine Hydroxylase Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.

Poids moléculaire: '60 kDa

ID gène: 25085

UniProt: P04177

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour