PLK1 anticorps (pThr210)
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- Antigène Voir toutes PLK1 Anticorps
- PLK1 (Polo-Like Kinase 1 (PLK1))
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Épitope
- pThr210
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PLK1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- Specific for ~66k PLK phosphorylated at Thr210. Immunolabeling of the PLK band is completely blocked by (-phosphatase treatment.
- Réactivité croisée
- Humain, Rat (Rattus)
- Homologie
- bovine, canine, mouse, non-human primate, Xenopus, Zebrafish
- Purification
- Antigen Affinity Purified from Pooled Serum
- Immunogène
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr210 conjugated to KLH
- Top Product
- Discover our top product PLK1 Anticorps primaire
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- Indications d'application
- Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
- Stock
- -20 °C
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- Antigène
- PLK1 (Polo-Like Kinase 1 (PLK1))
- Autre désignation
- PLK1 (PLK1 Produits)
- Synonymes
- anticorps PLK, anticorps STPK13, anticorps plk, anticorps PLK-1, anticorps Plx1, anticorps stpk13, anticorps Plk, anticorps cb525, anticorps cb636, anticorps ik:tdsubc_2d1, anticorps wu:fb37g11, anticorps wu:fb76g03, anticorps xx:tdsubc_2d1, anticorps polo like kinase 1, anticorps polo like kinase 1 S homeolog, anticorps polo-like kinase 1, anticorps polo-like kinase 1 (Drosophila), anticorps Serine/threonine-protein kinase plk-1, anticorps PLK1, anticorps plk1.S, anticorps plk1, anticorps Plk1, anticorps plk-1
- Sujet
- Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK?s is detected in many types of cancer and associated with oncogenesis (Takei et al., 2005). It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210 (van de Weerdt et al., 2005). Anti-Phospho-Thr210 PLK1 Western blot of rat synaptic membrane showing specific immunolabeling of the ~66 k PLK protein phosphorylated at Thr210 (control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the phospho-Thr210 PLK antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
- Poids moléculaire
- '66 kDa
- ID gène
- 5347
- UniProt
- P53350
- Pathways
- Cycle Cellulaire, M Phase
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