SCN9A anticorps (AA 1751-1946)

N° du produit ABIN361773

Cité dans 1 publication. Cet anticorps anti-SCN9A Monoclonal Souris (Clone N68-6 (Formerly S68-6)) (ABIN361773) détecte spécifiquement SCN9A dans IHC, WB, IF, IP, ICC et AA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SCN9A anticorps (AA 1751-1946) (ABIN361773)

Antigène: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCN9A est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)

Clone: N68-6 (Formerly S68-6)

Détail du produit anti-SCN9A anticorps

Épitope: AA 1751-1946

Specificité: Detects ~230 kDa. No cross-reactivity against other Nav channels.

Réactivité croisée: Hamster, Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN361773 was sufficient for detection of Nav1.7 in 10 μg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Références pour anticorps anti-SCN9A (ABIN361773)

Ngwainmbi, De, Smith, El-Hage, Fitting, Kang, Dewey, Hauser, Akbarali: "Effects of HIV-1 Tat on enteric neuropathogenesis." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14243-51, (2014) (PubMed).

Détails sur SCN9A

Antigène: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Autre désignation: Nav1.7

Sujet: Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).

ID gène: 6335

NCBI Accession: NP_002968

UniProt: Q15858