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SCN9A anticorps (AA 1751-1946)

SCN9A Reactivité: Humain IHC, WB, IF, IP, ICC, AA Hôte: Souris Monoclonal N68-6 (Formerly S68-6) unconjugated
N° du produit ABIN361773
  • Antigène Voir toutes SCN9A Anticorps
    SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
    Épitope
    • 11
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1751-1946
    Reactivité
    • 41
    • 14
    • 10
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 25
    • 17
    • 1
    • 1
    Souris
    Clonalité
    • 27
    • 17
    Monoclonal
    Conjugué
    • 22
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SCN9A est non-conjugé
    Application
    • 25
    • 22
    • 14
    • 12
    • 12
    • 12
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificité
    Detects ~230 kDa. No cross-reactivity against other Nav channels.
     Réactivité croisée
    Hamster, Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
    Clone
    N68-6 (Formerly S68-6)
    Isotype
    IgG1
  • Indications d'application
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN361773 was sufficient for detection of Nav1.7 in 10 μg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Ngwainmbi, De, Smith, El-Hage, Fitting, Kang, Dewey, Hauser, Akbarali: "Effects of HIV-1 Tat on enteric neuropathogenesis." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14243-51, (2014) (PubMed).

  • Antigène
    SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
    Autre désignation
    Nav1.7 (SCN9A Produits)
    Synonymes
    anticorps SCN9A, anticorps DKFZp459G084, anticorps Nav1.7, anticorps PN1, anticorps mKIAA4197, anticorps Scn2a, anticorps ETHA, anticorps FEB3B, anticorps GEFSP7, anticorps NE-NA, anticorps NENA, anticorps SFNP, anticorps sodium channel, voltage-gated, type IX, alpha subunit, anticorps sodium voltage-gated channel alpha subunit 9, anticorps sodium channel protein type 9 subunit alpha, anticorps sodium channel, voltage-gated, type IX, alpha, anticorps SCN9A, anticorps LOC100016648, anticorps Scn9a
    Sujet
    Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).
    ID gène
    6335
    NCBI Accession
    NP_002968
    UniProt
    Q15858
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