EPAS1 anticorps (AA 535-631)

N° du produit ABIN363209

L’anticorps Souris Monoclonal anti-EPAS1 a été validé pour WB, IHC, ELISA, IP, ICC, FACS, IF et ChIP. Il convient pour détecter EPAS1 dans des échantillons de Humain, Rat, Souris et Hamster.

Aperçu rapide pour EPAS1 anticorps (AA 535-631) (ABIN363209)

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reactivité: Humain, Rat, Souris, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EPAS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)

Clone: Ep190b

Détail du produit anti-EPAS1 anticorps

Épitope: AA 535-631

Specificité: Reacts with HIF-2 alpha from human, mouse hamster and rat

Réactivité croisée (Details): Does not cross-react with HIF-1 alpha.

Purification: Purified (protein G)

Immunogène: Human HIF-2 alpha amino acids 535-631

Isotype: IgG1

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
ELISA1:100-1:2000, FC1:400, IHC1:150-1:300, WB1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, Sodium azide 0.1 %

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Détails sur EPAS1

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Autre désignation: Hypoxia-Inducible Factor 2-alpha

Sujet: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

ID gène: 2034

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg