APEX1 anticorps

N° du produit ABIN363379

Cet anticorps Lapin Polyclonal détecte spécifiquement APEX1 dans WB, IHC, IF, ICC, ChIP, IP et Neut. Il présente une réactivité avec des échantillons de Humain, Souris, Rat et Lapin.

Aperçu rapide pour APEX1 anticorps (ABIN363379)

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Reactivité: Humain, Souris, Rat, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APEX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), Neutralization (Neut)

Détail du produit anti-APEX1 anticorps

Specificité: Reacts with human ~37 kDa APE-1 protein

Réactivité croisée: Souris, Lapin, Rat (Rattus)

Réactivité croisée (Details): Cross reacts with proteins from mouse, rat and rabbit.

Purification: Antigen affinity purified

Immunogène: Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC: 1/1 000 - WB : 1/1 000 - B/N: 50-200 Molar excess - ChIP: 1/10-1/500 - ICC/IF: 1/50-1/200 - IP: 7 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Tris-glycine, NaCl 150 mM buffer, Sodium azide 0.05 %

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Détails sur APEX1

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Autre désignation: DNA-(Apurinic Or Apyrimidinic Site) Lyase (APE-1)

Sujet: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.

ID gène: 328

Pathways: Réparation de l'ADN, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus