Transferrin Receptor anticorps (Biotin)

N° du produit ABIN370994

L’anticorps Rat Monoclonal anti-Transferrin Receptor a été validé pour FACS. Il convient pour détecter Transferrin Receptor dans des échantillons de Souris.

Aperçu rapide pour Transferrin Receptor anticorps (Biotin) (ABIN370994)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Clone: RI7217

Détail du produit anti-Transferrin Receptor anticorps (Biotin)

Specificité: This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions).

Attributs du produit: Synonyms: TfR1, p90, Transferrin receptor protein 1

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.1-3,5)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: CD71 / TFRC

Sujet: CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. Clone RI7217 inhibits cell proliferation in vitro. (Ref.2)Synonyms: TfR1, Transferrin receptor protein 1, p90

ID gène: 22042

UniProt: Q62351

Pathways: Transition Metal Ion Homeostasis