CTLA4 anticorps

N° du produit ABIN371060

Détail du produit anti-CTLA4 anticorps

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Specificité: This Monoclonal antibody is specific to CD152/CTLA-4 costimulatory receptor (Mr. 69 kDa)

Attributs du produit: Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

niveau d'endotoxine: Low Endotoxin

Immunogène: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusionprotein. (Ref. 1)

Clone: 9H10

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry. Immunoprecipitation. In vitro and in vivo blocking of CTLA-4 action by soluble antibody. Promotion of in vitro CTLA-4 signalling by cross-linked antibody. See Ref.1 for more details.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing no preservatives.

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquous) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CD152 / CTLA4 (CTLA4 Produits)

Synonymes: anticorps CTLA-4, anticorps CTLA4, anticorps CD152, anticorps Cd152, anticorps Ctla-4, anticorps Ly-56, anticorps CD, anticorps CELIAC3, anticorps GRD4, anticorps GSE, anticorps IDDM12, anticorps sCTLA4, anticorps cytotoxic T-lymphocyte associated protein 4, anticorps cytotoxic T-lymphocyte-associated protein 4, anticorps CTLA4, anticorps Ctla4

Sujet: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. (Ref.1,2) Like CD28, the CD152 Molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. (Ref.3) CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. (Ref.1,3,4) Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2. (Ref.1,5,6)Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

ID gène: 100505288

UniProt: P09793

Pathways: Cancer Immune Checkpoints