MMP1 anticorps (HRP)

N° du produit ABIN371652

Détail du produit anti-MMP1 anticorps (HRP)

Antigène: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMP1 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: This antibody is specific for Human MMP-1. Does not cross react to human MMP-2, MMP-3 or MMP-9.

Attributs du produit: Synonyms: Interstitial collagenase, Matrix metalloproteinase-1, Fibroblast collagenase, MMP1, CLG

Immunogène: Recombinant MMP-1.

Clone: SB12e

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/1,000-1/4,000. Western Blot. Immunohistochemistry (Frozen/Paraffin): 1/1,000-1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 % Glycerol/50 % PBS, pH 7.4 without preservatives.

Agent conservateur: Without preservative

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MMP1

Antigène: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Autre désignation: MMP-1 (MMP1 Produits)

Synonymes: anticorps CLG, anticorps CLGN, anticorps Mmp1a, anticorps CG4859, anticorps Dm1-MMP, anticorps Dmel\\CG4859, anticorps MMP-1, anticorps MMP1, anticorps Mmp 1, anticorps dMMP1, anticorps dm1-MMP, anticorps dmmp1, anticorps l(2)k04809, anticorps mmp1, anticorps Mmp1, anticorps Mcol-A, anticorps Mcola, anticorps col4, anticorps mmp18, anticorps Clgn, anticorps matrix metallopeptidase 1, anticorps Matrix metalloproteinase 1, anticorps matrix metalloproteinase 1, anticorps matrix metallopeptidase 1 (interstitial collagenase), anticorps matrix metallopeptidase 1a (interstitial collagenase), anticorps matrix metallopeptidase 1 S homeolog, anticorps interstitial collagenase, anticorps matrix metallopeptidase 8 L homeolog, anticorps MMP1, anticorps Mmp1, anticorps RB11133, anticorps Mmp1a, anticorps mmp1.S, anticorps LOC100727966, anticorps mmp8.L

Sujet: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP1, also known as interstitial collagenase, is the only enzyme that is able to initiate the breakdown of the interstitial collagens, types I, II, and IIISynonyms: CLG, Fibroblast collagenase, Interstitial collagenase, MMP1, Matrix metalloproteinase-1

ID gène: 4312

UniProt: P03956