TOLLIP anticorps

N° du produit ABIN371662

Cet anticorps Souris Monoclonal détecte spécifiquement TOLLIP dans WB, EIA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour TOLLIP anticorps (ABIN371662)

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOLLIP est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)

Clone: SB40a

Détail du produit anti-TOLLIP anticorps

Specificité: This antibody is specific to Human Tollip. Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins.

Attributs du produit: Synonyms: Toll-interacting protein

Purification: Purified

Immunogène: Recombinant Tollip.

Isotype: IgG2a

Information d'application

Indications d'application: ELISA. Western Blot. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TOLLIP

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Autre désignation: TOLLIP

Sujet: Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP.Synonyms: Toll-interacting protein

ID gène: 54472

UniProt: Q9H0E2