CGRP anticorps

N° du produit ABIN371823

Cet anticorps anti-CGRP est un anticorps Souris Monoclonal détectant CGRP dans IF et IHC (fro). Adapté pour Humain, Rat et Mammifères.

Aperçu rapide pour CGRP anticorps (ABIN371823)

Antigène: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Reactivité: Humain, Rat, Mammifères

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CGRP est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 4901

Détail du produit anti-CGRP anticorps

Specificité: This antibody is specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested Positive Controls: Dorsal root ganglia, pancreas and gut.

Réactivité croisée (Details): Species reactivity (expected):most Mammals.
Species reactivity (tested):Human and Rat.

Attributs du produit: Synonyms: Calcitonin gene-related peptide I, Alpha-type CGRP, CALC1, CGRP-I

Purification: Protein G Chromatography.

Isotype: IgG2a

Information d'application

Indications d'application: Immunocytochemistry: 1/50-1/100. Immunofluorescence and Immunohistochemistry: This antibody is an excellent tool forImmunohistochemistry and for multiple labeling immunofluorescence of peripheral tissuelike stomach, intestine, pancreas, sensory ganglia, and all the regions of the body that areinnervated by primary afferent neurons as well as central nervous tissue. Suggested Positive Controls: Dorsal root ganglia, pancreas and gut. Not recommended for Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CGRP

Antigène: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Autre désignation: CGRP / CALCA

Sujet: Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in Immunoneutralization (Wong et al., 1993)Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I

ID gène: 796

UniProt: P06881

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour