TLX1 anticorps (AA 300-330)

N° du produit ABIN372448

Cet anticorps Lapin Polyclonal détecte spécifiquement TLX1 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Souris, Humain et Rat.

Aperçu rapide pour TLX1 anticorps (AA 300-330) (ABIN372448)

Antigène: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TLX1 anticorps

Épitope: AA 300-330

Specificité: This antibody recognizes Homeobox Protein Hox-11 (TLX1).

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogène: Synthetic peptide corresponding to a portion of amino acids 300-330 of human HOX11.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur TLX1

Antigène: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Autre désignation: TLX1

Sujet: HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35,q24) or t(10:14)(q24,qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.Synonyms: HOX11, Hox-11, T-cell leukemia homeobox protein 1, T-cell leukemia/lymphoma protein 3, TCL-3, TCL3, TLX-1

ID gène: 3195

NCBI Accession: NP_005512

UniProt: P31314