Ephrin B1 anticorps (pTyr317)

N° du produit ABIN372620

Détail du produit anti-Ephrin B1 anticorps

Antigène: Ephrin B1 (EFNB1)

Épitope: pTyr317

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Poulet, Boeuf (Vache), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin B1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~46k Ephrin-B protein phosphorylated at Tyr317. Immunolabeling of the Ephrin-B band is blocked by lambda-phosphatase treatment

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Chicken, Mouse, Xenopus and Zebrafish.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho Tyr317 of Chicken Ephrin-B.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur Ephrin B1

Antigène: Ephrin B1 (EFNB1)

Autre désignation: Ephrin-B1 (EFNB1 Produits)

Synonymes: anticorps EFNB1, anticorps LERK2, anticorps Cek5-L, anticorps EFL-3, anticorps Elk-L, anticorps Epl2, anticorps Eplg2, anticorps LERK-2, anticorps Lerk2, anticorps Stra1, anticorps CFND, anticorps CFNS, anticorps EFL3, anticorps EPLG2, anticorps cfnd, anticorps cfns, anticorps efl3, anticorps efnb1-A, anticorps ephrinB1, anticorps eplg2, anticorps lerk2, anticorps ephrin B1, anticorps ephrin-B1, anticorps ephrin-B1 L homeolog, anticorps EFNB1, anticorps Efnb1, anticorps efnb1, anticorps efnb1.L

Sujet: Ephrin-B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vancerhaeghen, 1998, Dufour et al., 2003, Oike et al., 2002). Ephrin-B molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin-B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin-B is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific Ephrin-B residue (Tyr298) plays a key role in Ephrin-B signaling (Kalo, et al., 2001).Synonyms: CEK5 LIgand, CEK5-L, EFL-3, EFL3, EFNB1, ELK-L, EPH-related receptor tyrosine kinase ligand 2, EPLG2, LERK-2, LERK2

ID gène: 395896

NCBI Accession: NP_990366

UniProt: O73612

Pathways: Signalisation RTK