GABBR2 anticorps (pSer783)

N° du produit ABIN372643

Cet anticorps Lapin Polyclonal détecte spécifiquement GABBR2 dans WB et IF. Il présente une réactivité envers Humain, Rat, Souris, Boeuf (Vache), Chien, Poulet et Non-Human Primate.

Aperçu rapide pour GABBR2 anticorps (pSer783) (ABIN372643)

Antigène: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Poulet, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABBR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-GABBR2 anticorps

Épitope: pSer783

Specificité: Specific for ~102k GABAB R2 phosphorylated at Ser783. Immunolabeling of the GABAB R2 band is completely blocked by lambda-phosphatase treatment.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Chicken, Mouse, Xenopus and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephospho-peptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser783 of GABAB R2.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000. Immunofluorescence: 1/500 (See Ref.1)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur GABBR2

Antigène: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Autre désignation: GABBR2

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).Synonyms: G-protein coupled receptor 51, GABA-B receptor 2, GABA-B-R2, GABBR-2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, Gb2, HG20

ID gène: 83633

NCBI Accession: NP_113990

UniProt: O88871

Pathways: cAMP Metabolic Process