PLK1 anticorps (pThr210)
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- Antigène Voir toutes PLK1 Anticorps
- PLK1 (Polo-Like Kinase 1 (PLK1))
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Épitope
- pThr210
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Reactivité
- Humain, Souris, Rat, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio), Xenopus laevis, Non-Human Primate
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PLK1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- This antibody recognizes the ~66k PLK protein phosphorylated at Thr210. Immunolabeling of the PLK band is completely blocked by lambda-phosphatase treatment.
- Réactivité croisée (Details)
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Species reactivity (expected):Bovine, Canine, Mouse, Xenopus, Zebrafish and non-Human Primates.
Species reactivity (tested):Rat and Human. - Purification
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
- Immunogène
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr210 of PLK1.
- Isotype
- IgG
- Top Product
- Discover our top product PLK1 Anticorps primaire
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- Indications d'application
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Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Antigène
- PLK1 (Polo-Like Kinase 1 (PLK1))
- Autre désignation
- PLK1 (PLK1 Produits)
- Synonymes
- anticorps PLK, anticorps STPK13, anticorps plk, anticorps PLK-1, anticorps Plx1, anticorps stpk13, anticorps Plk, anticorps cb525, anticorps cb636, anticorps ik:tdsubc_2d1, anticorps wu:fb37g11, anticorps wu:fb76g03, anticorps xx:tdsubc_2d1, anticorps polo like kinase 1, anticorps polo like kinase 1 S homeolog, anticorps polo-like kinase 1, anticorps polo-like kinase 1 (Drosophila), anticorps Serine/threonine-protein kinase plk-1, anticorps PLK1, anticorps plk1.S, anticorps plk1, anticorps Plk1, anticorps plk-1
- Sujet
- Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK's is detected in many types of cancer and associated with oncogenesis (Takei et al., 2005). It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210 (van de Weerdt et al., 2005).Synonyms: PLK-1, Polo-like kinase 1, STPK13, Serine/threonine-protein kinase PLK1
- ID gène
- 5347
- NCBI Accession
- NP_005021
- UniProt
- P53350
- Pathways
- Cycle Cellulaire, M Phase
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