SYN1 anticorps (pSer62, pSer67)
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- Antigène Voir toutes SYN1 Anticorps
- SYN1 (Synapsin I (SYN1))
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Épitope
- pSer62, pSer67
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Reactivité
- Souris, Rat, Boeuf (Vache)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SYN1 est non-conjugé
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Application
- Western Blotting (WB), Dot Blot (DB)
- Specificité
- This antibody recognizes the ~78k Synapsin I doublet phosphorylated at Ser62,67. Immunolabeling of the Synapsin I band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.
- Réactivité croisée (Details)
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Species reactivity (expected):Bovine (100 %) and Mouse (100 %).
Species reactivity (tested):Rat. - Purification
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns
- Immunogène
- Phosphopeptide corresponding to amino acid residues surrounding the Phospho Serine 62,67 of Synapsin I.
- Isotype
- IgG
- Top Product
- Discover our top product SYN1 Anticorps primaire
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- Indications d'application
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Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, None, 100 μg/mL BSA and 50 % Glycerol
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody undiluted (in aliquots) at-20 °C.
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In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation." dans: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 174-81, (2008) (PubMed).
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In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation." dans: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 174-81, (2008) (PubMed).
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- Antigène
- SYN1 (Synapsin I (SYN1))
- Autre désignation
- Synapsin-1 (SYN1 Produits)
- Synonymes
- anticorps SYN1a, anticorps SYN1b, anticorps SYNI, anticorps Syn-1, anticorps SYN I, anticorps si:dkey-90n12.3, anticorps synapsin I, anticorps synapsin I L homeolog, anticorps SYN1, anticorps Syn1, anticorps syn1.L, anticorps syn1
- Sujet
- Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987, Jovanovic et al., 1996).Synonyms: Brain protein 4.1, SYN1, Synapsin I
- ID gène
- 6853
- NCBI Accession
- NP_008881
- UniProt
- P17600
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