SYN1 anticorps (pSer603)

N° du produit ABIN372721

Cet anticorps Lapin Polyclonal détecte spécifiquement SYN1 dans WB. Il présente une réactivité envers Humain, Rat, Souris, Boeuf (Vache), Xenopus laevis et Poisson zèbre (Danio rerio).

Aperçu rapide pour SYN1 anticorps (pSer603) (ABIN372721)

Antigène: SYN1 (Synapsin I (SYN1))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Xenopus laevis, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYN1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SYN1 anticorps

Épitope: pSer603

Specificité: This antibody recognizes ~78k Synapsin I doublet protein phosphorylated at Ser603. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Mouse, Xenopus and Zebrafish.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser603 of Synapsin I.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur SYN1

Antigène: SYN1 (Synapsin I (SYN1))

Autre désignation: Synapsin-1

Sujet: Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases (Sakurada et al., 2002, Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function (Nayak et al., 1996, Bahler and Greengard, 1987, McGuinness et al., 1989).Synonyms: Brain protein 4.1, SYN1, Synapsin I

ID gène: 6853

NCBI Accession: NP_008881

UniProt: P17600