SYN1 anticorps (pSer603)
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- Antigène Voir toutes SYN1 Anticorps
- SYN1 (Synapsin I (SYN1))
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Épitope
- pSer603
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Xenopus laevis, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SYN1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- This antibody recognizes ~78k Synapsin I doublet protein phosphorylated at Ser603. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment.
- Réactivité croisée (Details)
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Species reactivity (expected):Human, Bovine, Mouse, Xenopus and Zebrafish.
Species reactivity (tested):Rat. - Purification
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
- Immunogène
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser603 of Synapsin I.
- Isotype
- IgG
- Top Product
- Discover our top product SYN1 Anticorps primaire
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- Indications d'application
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Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Antigène
- SYN1 (Synapsin I (SYN1))
- Autre désignation
- Synapsin-1 (SYN1 Produits)
- Synonymes
- anticorps SYN1a, anticorps SYN1b, anticorps SYNI, anticorps Syn-1, anticorps SYN I, anticorps si:dkey-90n12.3, anticorps synapsin I, anticorps synapsin I L homeolog, anticorps SYN1, anticorps Syn1, anticorps syn1.L, anticorps syn1
- Sujet
- Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases (Sakurada et al., 2002, Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function (Nayak et al., 1996, Bahler and Greengard, 1987, McGuinness et al., 1989).Synonyms: Brain protein 4.1, SYN1, Synapsin I
- ID gène
- 6853
- NCBI Accession
- NP_008881
- UniProt
- P17600
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