MAPT anticorps (pSer416)

N° du produit ABIN372727

Cet anticorps Lapin Polyclonal détecte spécifiquement MAPT dans WB. Il présente une réactivité envers Humain, Rat, Souris, Boeuf (Vache), Chien et Non-Human Primate.

Aperçu rapide pour MAPT anticorps (pSer416) (ABIN372727)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MAPT anticorps

Épitope: pSer416

Specificité: Specific for ~59, 65, 68k Tau protein phosphorylated at Ser416.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Canine, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography via sequential chromatography on phospho- and dephospho-peptide affinity columns

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of Rat MAPT/TAU.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT / tau

Sujet: Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer's disease (AD), Pick's disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990).Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

ID gène: 10116

UniProt: P19332

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size