MAPT anticorps (pSer416)

N° du produit ABIN372727

Détail du produit anti-MAPT anticorps

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Épitope: pSer416

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for ~59, 65, 68k Tau protein phosphorylated at Ser416.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Canine, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography via sequential chromatography on phospho- and dephospho-peptide affinity columns

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of Rat MAPT/TAU.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT / tau (MAPT Produits)

Synonymes: anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps AI413597, anticorps AW045860, anticorps Mtapt, anticorps Tau, anticorps RNPTAU, anticorps pTau, anticorps tau, anticorps xtp, anticorps MAPT, anticorps PHF-tau, anticorps slc6a6, anticorps taut, anticorps wu:fc26e12, anticorps microtubule associated protein tau, anticorps microtubule-associated protein tau, anticorps microtubule associated protein tau S homeolog, anticorps Microtubule-associated protein tau, anticorps solute carrier family 6 (neurotransmitter transporter), member 6b, anticorps MAPT, anticorps Mapt, anticorps mapt.S, anticorps LOC5580230, anticorps CpipJ_CPIJ013260, anticorps tau, anticorps slc6a6b

Sujet: Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer's disease (AD), Pick's disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990).Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

ID gène: 10116

UniProt: P19332

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size