IL7R anticorps (pTyr449)

N° du produit ABIN372989

Détail du produit anti-IL7R anticorps

Antigène: IL7R (Interleukin 7 Receptor (IL7R))

Épitope: pTyr449

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL7R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes Interleukin 7 Receptor Alpha Chain (IL7R). This phospho-specific polyclonal antibody reacts with Mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.

Réactivité croisée (Details): Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide corresponding to residues near Tyr449 of Mouse IL-7 protein

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 5 μg/mL. Western blot: 1/1000 - 1/10000. ELISA: 1/100000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, pH 7.2 with 0.15 M Sodium Chloride, 0.01 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur IL7R

Antigène: IL7R (Interleukin 7 Receptor (IL7R))

Autre désignation: CD127 / IL7R (IL7R Produits)

Synonymes: anticorps IL7R, anticorps CD127, anticorps IL-7Ralpha, anticorps CDW127, anticorps IL-7R-alpha, anticorps IL7RA, anticorps ILRA, anticorps IL-7RA, anticorps interleukin 7 receptor, anticorps IL7R, anticorps Il7r

Sujet: Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).Synonyms: IL-7R-alpha, IL7 receptor alpha, Interleukin-7 receptor subunit alpha

ID gène: 3575

NCBI Accession: NP_002176

UniProt: P16871

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size