PAI1 anticorps (Internal Region)

N° du produit ABIN374547

Cité dans 1 publication. Cet anticorps anti-PAI1 Polyclonal Chèvre (ABIN374547) détecte spécifiquement PAI1 dans WB, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain et Chien.

Aperçu rapide pour PAI1 anticorps (Internal Region) (ABIN374547)

Antigène: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivité: Humain, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PAI1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-PAI1 anticorps

Épitope: Internal Region

Séquence: C-GFKIDDKGMA PALRH

Réactivité croisée (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Synthetic peptide (C-GFKIDDKGMAPALRH) from the internal region of SERPINE1 (NP_000593.1, NP_001158885.1). Genename: SERPINE1

Information d'application

Indications d'application: Peptide ELISA: 1/16000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-PAI1 (ABIN374547)

Cipollone, Felicioni, Sarzani, Ucchino, Spigonardo, Mandolini, Malatesta, Bucci, Mammarella, Santovito, de Lutiis, Marchetti, Mezzetti, Buttitta: "A unique microRNA signature associated with plaque instability in humans." dans: Stroke, Vol. 42, Issue 9, pp. 2556-63, (2011) (PubMed).

Détails sur PAI1

Antigène: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Autre désignation: SERPINE1 / PAI1

Sujet: PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1

Poids moléculaire: 45.1 kDa (NP_000593.1)

NCBI Accession: NM_000602

UniProt: P05121

Pathways: Signalisation p53, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration