PHLPP2 anticorps (C-Term)

N° du produit ABIN374772

Cet anticorps anti-PHLPP2 Polyclonal Chèvre (ABIN374772) détecte spécifiquement PHLPP2 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PHLPP2 anticorps (C-Term) (ABIN374772)

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PHLPP2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PHLPP2 anticorps

Épitope: C-Term

Specificité: This antibody reacts to PHLPP2.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-PHEEDRTEPPEEFD, from the C Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PHLPP2

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Autre désignation: PHLPP2

Sujet: PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro and antiapoptotic genes. Dephosphorylation of Ser 473 of AKT1 triggers apoptosis and decrease cell proliferation. PHLPP2 also controls the phosphorylation of AKT3. It binds 2 manganese ions per subunit. There are 3 named isoforms produced by alternative splicing.Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL

ID gène: 23035

NCBI Accession: NP_055835

UniProt: Q6ZVD8

Pathways: Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway