IL12B anticorps (Internal Region)

N° du produit ABIN374932

Cet anticorps Chèvre Polyclonal détecte spécifiquement IL12B dans WB. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour IL12B anticorps (Internal Region) (ABIN374932)

Antigène: IL12B (Interleukin 12 beta (IL12B))

Reactivité: Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL12B anticorps

Épitope: Internal Region

Séquence: C-EARQQNKYEN YS

Specificité: This antibody reacts to Il12b / Il12p40.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_032378.1.

Information d'application

Indications d'application: Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Aazide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur IL12B

Antigène: IL12B (Interleukin 12 beta (IL12B))

Autre désignation: Interleukin-12 beta / IL12B

Sujet: Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2

ID gène: 3593

NCBI Accession: NP_002178

UniProt: P29460

Pathways: Signalistation JAK/STAT, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation