AICDA anticorps (N-Term)

N° du produit ABIN374978

L’anticorps anti-AICDA Polyclonal Chèvre est utilisé pour la détection de AICDA dans des échantillons de Humain, Boeuf (Vache) et Porc. Il a été validé pour WB et EIA.

Aperçu rapide pour AICDA anticorps (N-Term) (ABIN374978)

Antigène: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reactivité: Humain, Boeuf (Vache), Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp AICDA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-AICDA anticorps

Épitope: N-Term

Specificité: This antibody reacts to AID.

Réactivité croisée (Details): Species reactivity (expected):Pig, Cow.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence RRKFLYQFKNVR-C, from the N Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/1000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur AICDA

Antigène: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Autre désignation: AICDA / AID

Sujet: AID or AICDA (activation-induced cytidine deaminase) is an RNA editing deaminase involved in somatic hypermutation, gene conversion, and class switch recombination. Expression of AID is restricted to stimulated B lymphocytes and it is required for several crucial steps of B cell terminal differentiation necessary for efficient antibody responses. It catalyses the deamination of Cytidine to uridine and ammonia and is strongly expressed in lymph nodes and tonsils. Defects in AICDA are the cause of autosomal recessive hyper IgM immunodeficiency syndrome type 2 (HIGM2) which is characterized by normal or elevated serum IgM levels with the absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections.Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase

ID gène: 57379, 9606

UniProt: Q9GZX7

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response