BAG5 anticorps (Internal Region)

N° du produit ABIN375061

Cet anticorps Chèvre Polyclonal détecte spécifiquement BAG5 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour BAG5 anticorps (Internal Region) (ABIN375061)

Antigène: BAG5 (BCL2-Associated Athanogene 5 (BAG5))

Reactivité: Humain, Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BAG5 anticorps

Épitope: Internal Region

Specificité: This antibody reacts to BAG5. This antibody is expected to recognise reported isoform a and isoform b.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence DPQGEEKCKAARKQ, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/16000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BAG5

Antigène: BAG5 (BCL2-Associated Athanogene 5 (BAG5))

Autre désignation: BAG5

Sujet: BAG5 is a member of the BAG1 related protein family. BAG1 is an anti apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL 2, Raf protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. A BAG domain near the C terminus, may bind and inhibit the chaperone activity of Hsc70/Hsp70. It has been hypothesized that the BAG5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70's anti apoptotic function. It is believed that BAG5 will play an important role in the mechanisms of neuronal death. BAG5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/modulation of other BAG containing proteins via BAG-BAG heterodimerization.Synonyms: BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5, KIAA0873

ID gène: 9529, 9606

UniProt: Q9UL15

Pathways: SARS-CoV-2 Protein Interactome