IL2 Receptor beta anticorps

N° du produit ABIN376384

Cet anticorps Rat Monoclonal détecte spécifiquement IL2 Receptor beta dans FACS et IP. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour IL2 Receptor beta anticorps (ABIN376384)

Antigène: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IL2 Receptor beta est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: 5H4

Détail du produit anti-IL2 Receptor beta anticorps

Fonction: Rat Anti-Mouse CD122-LE/AF

Specificité: Mouse CD122, 90-100 kDa

Attributs du produit: Low Endotoxin/Azide Free Anti-Mouse CD122 antibody for use in flow cytometry and immunoprecipitation assays.

niveau d'endotoxine: Low Endotoxin

Immunogène: Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-m-beta-t-28)

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur IL2 Receptor beta

Antigène: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Autre désignation: CD122

Sujet: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity, (ii) the β chain that binds IL-2 with high affinity, and (ii) the common γ chain ( γ C ) that does not bind IL-2. The high affinity receptor complex is an α / β / γ heterotrimer with a K d of 1.3 x 10 -11 M. In mouse spleen, CD122 is expresed on approx. 30 % of CD8 + cells and all NK cells, but < 1 % of B cells and CD4 + T lymphocytes. In the thymus, its expression is confined to CD4 - CD8 + single positive and CD4 - CD8 - double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.

ID gène: 16185

UniProt: P16297

Pathways: Signalistation JAK/STAT, Growth Factor Binding