IL2 Receptor beta anticorps (PE)

N° du produit ABIN376503

Cet anticorps anti-IL2 Receptor beta est un anticorps Rat Monoclonal détectant IL2 Receptor beta dans FACS. Adapté pour Souris.

Aperçu rapide pour IL2 Receptor beta anticorps (PE) (ABIN376503)

Antigène: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IL2 Receptor beta est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 5H4

Détail du produit anti-IL2 Receptor beta anticorps (PE)

Specificité: Mouse CD122, 90-100 kDa

Attributs du produit: Rat Anti-Mouse CD122-PE

Purification: Purified

Immunogène: Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-mbetat-28)

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IP - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE and APC conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: 0.1 mg in 1.0 mL of PBS/Sodium azide and a stabilizing agent

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze!
Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur IL2 Receptor beta

Antigène: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Autre désignation: CD122

Sujet: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity, (ii) the β chain that binds IL-2 with high affinity, and (ii) the common γ chain ( γ C ) that does not bind IL-2. The high affinity receptor complex is an α / β / γ heterotrimer with a K d of 1.3 x 10 -11 M. In mouse spleen, CD122 is expresed on approx. 30 % of CD8 + cells and all NK cells, but < 1 % of B cells and CD4 + T lymphocytes. In the thymus, its expression is confined to CD4 - CD8 + single positive and CD4 - CD8 - double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.

Pathways: Signalistation JAK/STAT, Growth Factor Binding